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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEPDC5
All Species:
11.82
Human Site:
Y397
Identified Species:
28.89
UniProt:
O75140
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75140
NP_001007189.1
1572
177910
Y397
D
S
R
L
G
D
D
Y
N
I
P
H
W
I
N
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_852875
773
87442
Cat
Felis silvestris
Mouse
Mus musculus
P61460
1527
173129
Y355
D
S
R
L
G
D
D
Y
N
I
P
H
W
I
N
Rat
Rattus norvegicus
NP_001100699
1456
164725
K323
K
S
A
T
E
K
T
K
N
G
R
D
T
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517877
828
93963
Chicken
Gallus gallus
XP_415249
1571
177723
Y397
D
S
R
L
G
D
D
Y
N
I
P
H
W
I
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_691450
1590
178752
G398
V
H
G
D
S
R
I
G
D
D
Y
N
L
P
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728620
1472
168864
V339
R
T
G
Q
L
S
V
V
I
T
P
G
V
G
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794020
1608
181354
D408
D
V
H
V
Q
R
G
D
Y
N
I
P
H
W
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7S9J6
2004
222187
Y575
L
A
Q
D
E
W
N
Y
A
L
P
Q
W
L
H
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
48
N.A.
91.7
87.4
N.A.
49.5
89.1
N.A.
75.5
N.A.
35.7
N.A.
N.A.
32.4
Protein Similarity:
100
N.A.
N.A.
48.6
N.A.
93.8
89.6
N.A.
50.9
94
N.A.
84.5
N.A.
53.7
N.A.
N.A.
48.6
P-Site Identity:
100
N.A.
N.A.
0
N.A.
100
13.3
N.A.
0
100
N.A.
0
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
N.A.
N.A.
0
N.A.
100
13.3
N.A.
0
100
N.A.
20
N.A.
13.3
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
35.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
0
0
0
0
0
10
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
40
0
0
20
0
30
30
10
10
10
0
10
0
0
0
% D
% Glu:
0
0
0
0
20
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
20
0
30
0
10
10
0
10
0
10
0
10
0
% G
% His:
0
10
10
0
0
0
0
0
0
0
0
30
10
0
20
% H
% Ile:
0
0
0
0
0
0
10
0
10
30
10
0
0
30
0
% I
% Lys:
10
0
0
0
0
10
0
10
0
0
0
0
0
0
0
% K
% Leu:
10
0
0
30
10
0
0
0
0
10
0
0
10
10
20
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
40
10
0
10
0
0
30
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
50
10
0
10
0
% P
% Gln:
0
0
10
10
10
0
0
0
0
0
0
10
0
0
0
% Q
% Arg:
10
0
30
0
0
20
0
0
0
0
10
0
0
0
0
% R
% Ser:
0
40
0
0
10
10
0
0
0
0
0
0
0
10
0
% S
% Thr:
0
10
0
10
0
0
10
0
0
10
0
0
10
0
0
% T
% Val:
10
10
0
10
0
0
10
10
0
0
0
0
10
0
10
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
0
40
10
0
% W
% Tyr:
0
0
0
0
0
0
0
40
10
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _